Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties
نویسندگان
چکیده
A simple, efficient, and general method has been developed for the synthesis of various α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, H-NMR, Cand P-NMR spectra. The X-ray crystallographic data of the representative compound 4l was determined. The new α-aminophosphonate derivatives were found to possess moderate to good antiviral activity.
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